** = shared first authorship    ——    $ = shared last authorship

SUBMITTED

N/A

2024

1. Mangena V, Chanoch-Myers R, Sartore R, Paulsen B, Gritsch S, Weisman H, Hara T, Breakefield XO, Breyne K, Regev A, Chung K, Arlotta P, Tirosh I, Suvà ML, Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer. Cancer Discovery, 2024 Oct 7. DOI: 10.1158/2159-8290.CD-23-1336.

2. Maksoud S, Schweiger MW, Tabet EL, Xiao T, El Hokayem J, Zinter M, Carvalho LA, Breyne K, Noske DP, Chiocca EA, and Tannous BA. Arming AAV9 with a Single-Chain Fragment Variable Antibody Against PD-1 for Systemic Glioblastoma Therapy. Mol Neurobiol. 2024 Aug 14. DOI: 10.1007/s12035-024-04406-y.

3. Schweiger MW, Amoozgar Z, Repiton P, Morris R, Maksoud S, Hla M, Zaniewski E, Noske DP, Haas W, Breyne K, and Tannous BA. Glioblastoma extracellular vesicles modulate immune PD-L1 expression in accessory macrophages upon radiotherapy. IScience. 2024 Jan 5;27(2):108807. DOI: 10.1016/j.isci.2024.108807. PMID: 38303726.

2023

1. Maalouf KE, Vaine CA, Frederick DM, Yoshinaga A, Obuchi W, Mahjoum S, Nieland L, Al Ali J, Bragg DC, Breakefield XO, and Breyne K. Tracking human neurologic disease status in mouse brain/plasma using reporter tagged, EV-associated biomarkers. Mol. Ther. 2023 July 5;31(7):2206-2219. Doi: 10.1016/j.ymthe.2023.05.011. PMID: 37198883.

2. Rufino-Ramos D, Leandro K, Perdigão PRL, O’Brien K, Pinto MM, Santana MM, van Solinge TS, Mahjoum S, Breakefield XO,  Breyne K ^$, and de Almeida LP ^$. Extracellular communication between brain cells through functional transfer of Cre mRNA. Mol. Ther. 2023 July 5;31(7):2220-2239. Doi: 10.1016/j.ymthe.2023.05.012. PMID: 37194237.

3. Vander Elst N, Bellemans J, Steenbrugge J, Geeroms C, Breyne K, Piepers S, Toledo-Silva B, de Souza FN, Haesebrouck F, De Vliegher S, Meyer E. Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study. Vet. Res. 2023 March; 54:28. Doi: 10.1186/s13567-023-01156-y. PMID: 36973819.

2022

1. Walachowski S, Breyne K, Secher T, Cougoule C, Guzylack L, Meyer E, Foucras G, and Tabouret G. Oral supplementation with yeast β-glucans improves the resolution of Escherichia coli-associated inflammatory responses independently of monocyte/macrophage immune training. Frontiers Immunology. Front. Immunol., 2022 December; 13. doi: 10.3389/fimmu.2022.1086413. PMID: 36605196.

2. Breyne K, Ughetto S, Rufino-Ramos D, Mahjoum S, Grandell EA, Pereira de Almeida L, and Breakefield XO. Exogenous loading of extracellular vesicles, virus-like particles, and lentiviral vectors with supercharged proteins. Commun Biol. 2022 May; 5: 485. doi: 10.1038/s42003-022-03440-7. PMID: 35590035

3. Rufino-Ramos D, Lule S, Mahjoum S, Ughetto S, Cristopher Bragg D, Pereira de Almeida L, Breakefield XO, Breyne K. Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo. Biomaterials. 2022 Feb; 281:121366. doi: 10.1016/j.biomaterials.2022.121366. PMID: 35033904

2020

1. Vander Elst N**, Breyne K**, Steenbrugge J, Gibson AJ, Smith DGE, Germon P, Werling D, Meyer E. Enterobactin Deficiency in a Coliform Mastitis Isolate Decreases Its Fitness in a Murine Model: A preliminary host-pathogen interaction study. Front Vet Sci. 2020; 7:576583. doi: 10.3389/fvets.2020.576583. PMID: 33240956.

2018

1. Tartaglia N**, Breyne K**, Cauty C, Jardin J, Chrétien D; Demeyere K, Berkova N, Azevedo V, Meyer E, and Guedon E. Staphylococcus aureus extracellular vesicles elicit an immunostimulatory response in experimental mouse of mastitis. Front Cell Infect Microbiol. 2018 Aug 22; 8: 277 doi: 10.3389/fcimb.2018.00277. PMID: 30186772.

2. Steenbrugge J, Breyne K, Demeyere K, De Wever O, Sanders N S, Van Den Broeck W, Colpaert C, Vermeulen P, Van Laere S, and Meyer E. Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer. J Exp Clin Cancer Res. 2018 Aug 15;37(1):191. doi: 10.1186/s13046-018-0860-x. PMID: 30111338.

3. Breyne K, Steenbrugge J, Demeyere K, Petzl W, Smith D, Germon P, and Meyer E. Immunomodulation of host chitinase 3-like 1 during a mammary pathogenic Escherichia coli infection. Front Immunol. 2018. May 28;9:1143. doi: 10.3389/fimmu.2018.01143. PMID: 29892291.

2017

1. Breyne K, Honaker RW, Hobbs Z, Richter M, Żaczek M, Spangler T, Steenbrugge J, Lu R, Kinkhabwala A, Marchon B, Meyer E, Mokres L. Efficacy and safety of a bovine-associated Staphylococcus aureus phage cocktail in a murine model of mastitis. Front Microbiol. 2017;8:2348. doi: 10.3389/fmicb.2017.02348. PMID: 29234314.

2. Breyne K, Steenbrugge J, Demeyere K, Vanden Berghe T, Meyer E. Preconditioning with lipopolysaccharide or lipoteichoic acid protects against Staphylococcus aureus mammary infection in mice. Front Immunol. 2017 Jul 24;8:833. doi: 10.3389/fimmu.2017.00833. PMID: 28791009.

2016

1. Steenbrugge J**, Breyne K**, Denies S, Dekimpe M, Demeyere K, De Wever O, Vermeulen P, Van Laere S, Sanders NN, Meyer E. Comparison of the adipose and luminal mammary gland compartment as orthotopic inoculation sites in a 4T1-based immunocompetent preclinical model for triple-negative breast cancer. J Mammary Gland Biol Neoplasia. 2016 Dec;21(3-4):113-122. doi: 10.1007/s10911-016-9362-7. PMID: 27714576.

2. Vermote A, Brackman G, Risseeuw MD, Vanhoutte B, Cos P, Van Hecke K, Breyne K, Meyer E, Coenye T, Van Calenbergh S. Hamamelitannin Analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus. Angew Chem Int Ed Engl. 2016 May 23;55(22):6551-6555. doi: 10.1002/anie.201601973. PMID: 27095479.

3. Peton V**, Breyne K**, Rault L, Demeyere K, Berkova N, Meyer E, Even S, Le Loir Y. Disruption of the sigS gene attenuates the local innate immune response to Staphylococcus aureus in a mouse mastitis model. Vet Microbiol. 2016 Apr 15;186:44-51. doi: 10.1016/j.vetmic.2016.02.014. PMID: 27016756.

4. Brackman G, Breyne K, De Rycke R, Vermote A, Van Nieuwerburgh F, Meyer E, Van Calenbergh S, Coenye T. The quorum sensing inhibitor hamamelitannin increases antibiotic susceptibility of Staphylococcus aureus biofilms by affecting peptidoglycan biosynthesis and eDNA release. Sci Rep. 2016 Feb 1;6:20321. doi: 10.1038/srep20321. PMID: 26828772.

2015

1. Breyne K, De Vliegher S, De Visscher A, Piepers S, Meyer E. Technical note: a pilot study using a mouse mastitis model to study differences between bovine associated coagulase-negative staphylococci. J Dairy Sci. 2015 Feb;98(2):1090-1100. doi: 10.3168/jds.2014-8699. PMID: 25497801.

2014

1. Breyne K, Cool SK, Demon D, Demeyere K, Vandenberghe T, Vandenabeele P, Carlsen H, Van Den Broeck W, Sanders NN, Meyer E. Non-classical proIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent. PLoS One. 2014 Aug 27;9(8):e105680. doi: 10.1371/journal.pone.0105680. PMID: 25162221.

2013

1. Demeyere K, Remijsen Q, Demon D, Breyne K, Notebaert S, Boyen F, Guérin CJ, Vandenabeele P, Meyer E. Escherichia coli induces bovine neutrophil cell death independent from caspase-3/-7/-1, but with phosphatidylserine exposure prior to membrane rupture. Vet Immunol Immunopathol. 2013 May 15;153(1-2):45-56. doi: 10.1016/j.vetimm.2013.02.003. PMID: 23510559

2. Cool SK, Breyne K, Meyer E, De Smedt SC, Sanders NN. Comparison of in vivo optical systems for bioluminescence and fluorescence imaging. J Fluoresc. 2013 Sep;23(5):909-920. doi: 10.1007/s10895-013-1215-9. PMID: 23579930.

3. Demon D, Breyne K, Schiffer G, Meyer E. Short communication: Antimicrobial efficacy of intramammary treatment with a novel biphenomycin compound against Staphylococcus aureus, Streptococcus uberis, and Escherichia coli-induced mouse mastitis. J Dairy Sci. 2013;96(11):7082-7087. doi: 10.3168/jds.2013-7011. PMID: 24054294. PMID: 25162221.

2012

1. Demon D, Ludwig C, Breyne K, Guédé D, Dörner JC, Froyman R, Meyer E. The intramammary efficacy of first generation cephalosporins against Staphylococcus aureus mastitis in mice. Vet Microbiol. 2012 Nov 9;160(1-2):141-50. doi: 10.1016/j.vetmic.2012.05.017. PMID: 22677480.

** = shared first authorship

SUBMITTED

N/A

PUBLISHED

1. Leandro K, Rufino-Ramos D, Breyne K ,  Di Ianni E, Lopes SM, Nobre RJ, Kleinstiver BP, Perdigão PRL, Breakefield XO, and de Almeida LP. Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads. Adv Drug Deliv Rev., 2024 Jun 5:115346. doi: 10.1016/j.addr.2024.115346. PMID: 38849005.

2. Lunavat TR, Nieland L, Vrijmoet AB, Zargani-Piccardi A, Samaha Y, Breyne K , and Breakefield XO. Roles of extracellular vesicles in glioblastoma: foes, friends and informers. Front. Oncol., 2023 Nov 24; 13:1291177. doi: 10.3389/fonc.2023.1291177. PMID: 38074665.

3. Nieland L, Mahjoum S, Grandell E, Breyne K, and Breakefield XO. Engineered EVs designed to target diseases of the CNS. J. Control. Release. 2023 Mar 10;S0168-3659(23)00176-1. doi: 10.1016/j.jconrel.2023.03.009. PMID: 36907561.

4. Aldoghachi AF, Aldoghachi AF, Breyne K , Ling KH and Cheah PS. Recent advances in therapeutic strategies for glioblastoma multiforme (GBM). Neuroscience Forefront Reviews. 2022 May 21;491:240-270. doi: 10.1016/j.neuroscience.2022.03.030. PMID: 35395355.

5. Chandler M, Johnson B, Khisamutdinov E, Dobrovolskaia MA, Sztuba-Solinska J, Salem AK, Breyne K , Chammas R, Walter NG, Contreras LM, Guo P, Afonin KA. The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The present and future of the burgeoning field. ACS Nano. 2021 Oct 22. doi: 10.1021/acsnano.0c10240. PMID: 34677049.

6. O’Brien K**, Breyne K**, Ughetto S, Laurent L C, and Xandra O. Breakefield. RNA delivery by extracellular vesicles in mammalian cells and its applications. Nature Reviews Molecular Cell Biology. 2020 1-22. doi: 10.1038/s41580-020-0251-y. PMID: 32457507.

1. Breyne K, and Meyer E. Infection of the Lactating Mammary Gland: Current Status on the Molecular Biology of Mastitis. Mammary Glands: Anatomy, Development and Diseases. Rucker EB, editor. Hauppauge, NY, USA: Nova Science Publishers; 2014. Chapter 6; p.141 – 172.